When you select yes for the wp-load.php directly option, have you moved your wp-content folders? As you can see underneath that option, this could cause issues.
You might also test to see if there is a plugin conflict. So deactivate all of your plugins except for Ajax Edit Comments and see if you are able to move a comment. If you can, turn your other plugins back on, one at a time testing AEC each time, to see which plugin is creating the issue.
Thanks,
Elise


