Hi,
Builder has child themes (Depot, Market, Threads, Thrifty) that are designed to be used in together with some of the more popular e-commerce plugins (Shopp, woocommerce, wp e-commerce, cart66). Builder as such does not have specific e-commerce features though, so you might want to check the various e-commerce plugins (and support) to see if the functionality you require is supported.
As far as layout and design in concerned, Builder can be used to built any site you want.
hope that helps,
Ronald
